
供biovendor Progranulin Human ELISA 欣博盛供
貨號:RMEE103R
名稱:Progranulin Human ELISA
規(guī)格:96 wells (1 kit)
產(chǎn)品描述:
progranulin也被稱為顆粒上皮前體,proepithin或acrogranin。它是一種68.5 kDa蛋白質(zhì),由593個氨基酸(包括信號肽)組成,在體內(nèi)以強(qiáng)糖基化形式出現(xiàn),因此其大小約為90 kDa。progranulin有七個保守域,由連接序列分離。通過蛋白水解酶分解,在絲氨酸蛋白酶(如彈性蛋白酶)的催化下,產(chǎn)生6-25kDa的大片段,稱為顆?;蛏掀ぁrogranulin尤其在腺樣體組織、脾臟、皮膚上皮、胃腸粘膜、造血細(xì)胞和腫瘤細(xì)胞等強(qiáng)增殖組織中表達(dá)和分泌。到目前為止,還沒有一種特定的受體能獲得前體蛋白或顆粒的作用。progranulin似乎是一個積極影響傷口愈合的因素。在皮膚損傷的情況下,在癌細(xì)胞、巨噬細(xì)胞和中性粒細(xì)胞中表達(dá)增加。progranulin通過激活巨噬細(xì)胞和刺激受損組織中的血管生成間接影響傷口愈合。前體蛋白和顆粒的生理作用是相反的。progranulin可抑制TNF介導(dǎo)的促炎過程。另一方面,顆粒似乎刺激促炎細(xì)胞因子的分泌。丙戊酸鈉對炎癥過程的影響也可在動脈硬化斑塊中表現(xiàn)出來。在這里,progranulin由平滑肌細(xì)胞表達(dá),并影響單核細(xì)胞和平滑肌細(xì)胞的遷移。在netual系統(tǒng)中,progranulin在小膠質(zhì)細(xì)胞和神經(jīng)元中表達(dá)(在新皮層和海馬錐體細(xì)胞以及小腦的浦肯野細(xì)胞中)。在mRNA水平上,在netual系統(tǒng)infect或損傷時,如I型和IIib型粘多發(fā)性脊髓灰質(zhì)炎、netual系統(tǒng)virus性炎癥、肌萎縮性側(cè)索硬化和阿爾茨海默氏癥時,可顯示出明顯的前體蛋白表達(dá)增加。除此之外,progranulin似乎與出生前和出生后性別特異性差異的發(fā)展以及成人的神經(jīng)可塑性有關(guān)。
特點:
It is suited for Progranulin determination in Serum and Plasma samples
It is extremely sensitive (18 pg/ml) and, thus allows measurements in cell culture media too and in specimens others than serum e.g. in Cerebrospinal fluid, Amnion fluid, Saliva, Urine, Breast milk - is fast: incubation time a total of 2 hours
Single Standards with 75, 250, 750, 1500, 2500 pg/ml human Progranulin are provided in the Kit
2 Control Sera are provided for quality control purposes according GLP
It is calibrated with recombinant Progranulin
Microtiter plates are separately breakapart, tests can be adapted to individual requirements
類型: Sandwich ELISA, Biotin-labelled antibody
別名:Myxovirus resistance protein 1
物種:Human
樣本濃度:10 μl/well
校準(zhǔn)范圍:75–2500 pg/ml
檢測限:0.018 ng/ml
應(yīng)用:Serum, Plasma
運輸:At ambient temperature. Upon receipt, store the product at the temperature recommended below.
儲存/到期:Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
產(chǎn)品覆蓋以下研究領(lǐng)域, 主要提供ELISA試劑盒,重組蛋白及相關(guān)抗體
凋亡(Apoptosis) |
糖尿病-胰島素、C-肽、胰島素原 (Diabetology - Insulin, C-Peptide, Proinsulin) |
肌生長調(diào)控 (Muscle Growth Control) |
自身免疫 (Autoimmunity) |
糖尿病-其他相關(guān)產(chǎn)品 (Diabetology - Other Relevant Products) |
神經(jīng)組織標(biāo)志物 (Neural Tissue Markers) |
血壓調(diào)節(jié)和NO代謝 (Blood Pressure Regulation And NO Metabolism) |
能量代謝和體重調(diào)節(jié) (Energy Metabolism And Body Weight Regulation) |
腫瘤學(xué) (Oncology) |
骨與軟骨代謝 (Bone And Cartilage Metabolism) |
生長hormone和生長因子相關(guān) (Growth Hormone And Factor-related Products) |
氧化應(yīng)激 (Oxidative Stress) |
心血管疾病 (Cardiovascular Disease) |
免疫應(yīng)答、infect和炎癥反應(yīng) (Immune Response, Infection And Inflammation) |
胰調(diào)控分子 (Pancreatic Regulatory Molecules) |
細(xì)胞粘連蛋白 (Cell Adhesion Proteins) |
免疫學(xué) (Immunology) |
腎臟疾病 (Renal Disease) |
細(xì)胞因子、趨化因子及相關(guān)分子 (Cytokines And Chemokines And Related Molecules) |
鐵代謝(Iron Metabolism) |
生殖 (Reproduction) |
糖尿病-自身免疫 (Diabetology – Autoimmunity) |
脂蛋白代謝 (Lipoprotein Metabolism) |
細(xì)胞表面蛋白 (Cell Surface Proteins (sCD) ) |
分泌型磷脂酶A2 (Secreted Phospholipases A2 show all) |
血清學(xué) (Serology) |
類固醇hormone (Steroid Hormones) |
移植 (Transplantation) |
動物相關(guān)研究 (Animal Studies) |
其他研究領(lǐng)域 (Others) |
產(chǎn)品編號 |
產(chǎn)品名稱 |
規(guī)格 |
檢測限 |
標(biāo)曲范圍 |
RD191009100 |
Human Cystatin C ELISA |
96 well |
0.25 ng/ml |
200–10 000 ng/ml |
RD191001100 |
Human Leptin ELISA, Clinical Range |
96 well |
0.2 ng/ml |
1–50 ng/ml |
RD194034200R |
Human Clusterin ELISA |
96 well |
0.5 ng/ml |
5–160 ng/ml |
RD194059100 |
Human Surfactant Protein D ELISA |
96 well |
0.01 ng/ml |
1.56–100 ng/ml |
RD191108200R |
Human Fibroblast Growth Factor-21 ELISA |
96 well |
7 pg/ml |
30–1920 pg/ml |
RD195023100 |
Human Adiponectin ELISA |
96 well |
26 ng/ml |
0.1–10 μg/ml |
RD191037100 |
Human Fetuin-A ELISA |
96 well |
0.104 ng/ml |
2–100 ng/ml |
RD191022200 |
Human Clara Cell Protein ELISA |
96 well |
46 pg/ml |
1.57–50 ng/ml |
RD193004200R |
Human sRANKL ELISA, total |
96 well |
0.4 pmol/l |
0.5–32 pmol/l |
RD194003200 |
Human Osteoprotegerin ELISA |
96 well |
0.03 pmol/l |
1.5–60 pmol/l |
詳情請咨詢Biovendor全國授權(quán)一級代理-欣博盛生物科技
全國服務(wù)熱線: 4006-800-892 郵箱: market@neobioscience.com
深圳: 0755-26755892 北京: 010-88594029 上海: 021-34613729
廣州:18024516375 香港: 852-69410778
代理品牌網(wǎng)站: www.nbs-bio.com
自主品牌網(wǎng)站: www.neobioscience.net